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Glucose tolerance test

Aim:

The Aim of the glucose tolerance test is to assess and quantify insulin sensitivity and investigate its biological potency.

Species:

The most suitable species for this test during non-clinical testing is pig or minipig.

Design and outcome:

After glucose challenge (intravenous injection) and administration of an insulin product the biological potency is evaluated by regular measurement of blood glucose and other parameters (e.g. plasma insulin). Evaluation of the measurements for the insulin product are compared to a negative control and/or a reference product.

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