Auri Knowledge
Start a conversation
Request Proposal
Auri Knowledge

Safety pharmacology core battery: Respiratory system

Aim:

The aim of this type of study is to evaluate the effects of the test item on the respiratory functions using Whole Body Plethysmography in freely moving animals.

Species:

In mice or rats.

Design:

  • Limit test or 3 dose group design (compared to one dose of positive control and a negative control)
  • In 2 sexes if sex differences are expected
  • Optional with exposure control at Cmax

Outcome:

Respiratory parameters are recorded and evaluated comparing to the pre-values and to the data gained from vehicle and positive control animals:

  • Inspiratory time
  • Expiratory time
  • Peak inspiratory flow
  • Peak expiratory flow
  • Tidal volume
  • Respiratory rate
  • Relaxation time
  • Enhanced pause
Start a conversation
Request Proposal
Auri Knowledge
Auri Knowledge