July 11, 2016
Skin irritation test is to assess the dermal irritation potency of the test item in rabbit.
Albino rabbits of either sex.
The test item is administered on both sides on the back (one side of the spine for test item and the other for control item). The sensitivity of the assay can be demonstrated with a positive control.
In an initial step the test will be performed in one animal. If no well-defined response is observed in the initial test, two addition animals are tested.
The skin reactions for erythema and edema and reversibility of findings are described and scored for each application site at defined time intervals.
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