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Support for formulation development

Aim:

The aim is to develop an animal test item dosing formulation to be administered in animal trials.

Procedure:

Simple animal dosing formulations, especially solutions are developed. The most frequently used cosolvents (ethanol, dimethyl sulfoxide, dimethyl formamide, PEG 300, PEG 400 etc) and surfactants (Kolliphor HS 15, Kolliphor EL, Polysorbate 80) are tested during the development of the formulation. The type and concentration of the vehicles is chosen on the basis of the solubility results and available toxicity data of the vehicles have to be also taken into consideration with emphasis on the possible species differences.

The quality of the formulation is checked by visual inspection and/or an in-house developed HPLC/UV method.

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